Dr. Santhosh  Penta

Department Department of Chemistry
Designation Assistant Professor
Educational Qualification Ph.D (NIT-Warangal)
E-Mail santhoshpenta07@gmail.com; spenta.che@nitrr.ac.in
Contact Number 8305654728
Areas of Interest
  • Synthetic Organic Chemistry
  • Heterocyclic Chemistry
  • Novel Methodologies
  • Drug Design of Pharmaceutical Importance




  1. Archi Sharmaa, Satish Gudalaa, Srinivasa Rao Ambatia,£, S. P. Mahapatraa, Soumen Payrac, Asif Razab, Aruna L. Vb, Anubhuti Jhad, Awanish Kumard, Santhosh Pentaa*, Subhash Banerjeec* On Water NiFe2O4 Nanoparticle-Catalyzed One-Pot Synthesis of Biofunctionalized Pyrimidine-Thiazole Derivatives: In-Silico Binding Affinity and In-Vitro Anti-Cancer Activity Studies. ChemistrySelect-2018, 3, 11012-11019
  2.  P. Srishylama, A., Shyamapada Banerjeea, Santhosh Penta and Yogesh S. Sanghvi Copper(II)nitrate catalyzed regioselective protection of primary alcohols with 4,4′-dimethoxytrityl and 2,7-dimethyl-9-phenyl xanthen-9-yl groups in nucleosides and carbohydrates. Nucleosides, Nucleotides and Nucleic Acids Volume 37, 2018 - Issue 4, 232-247
  3. P. Srishylama, A. Raji Reddya, Shyamapada Banerjeea, Santhosh Penta and Yogesh S. Sanghvi DDQ mediated regiospecific protection of primary alcohol and deprotection under neutral conditions: Application of new p-methoxy benzyl-pixyl ether as reagent of choice for nucleoside protection. Tetrahedron Letters, Volume 58, Issue 26, 28 June 2017, Pages 2588-2591
  4. Archi Sharma, Satish Gudala, Srinivasa Rao Ambati, Santhosh Penta,a*, Yashwanth Bomma, Venkateswara Rao Janapala, Anubhuti Jha and Awanish Kumar Synthesis, anti-cancer evaluation and molecular docking studies of novel 4-hydroxy-2-thioxo-3,4-dihydro-2H-[1,3]thiazin-6-yl)-chromen-2-ones via multi-component approach” Journal Of Chinese Chemical Society, Volume 65, Issue 7, June 2018, Pages 810–821
  5. Srinivasa Rao Ambati, Satish Gudala, Archi Sharma, Santhosh Penta, Velatooru Loka Reddy, Yashwanth Bomma, Venkateswara Rao Janapala, and Someshwar Pola. Facile Synthesis of Novel 3-(4-phenylisothiazol-5-yl)-2H-chromen-2-one Derivatives as Potential Anticancer Agents. Journal of Heterocyclic Chemistry, Volume 54, Issue 4, July 2017, Pages: 2333–2341
  6. Satish Gudala, Archi Sharma, V. Rajeswer Rao, Awanish Kumar, Santhosh Penta.  Recent developments in synthesis of embelin heterocyclic derivatives and their biological applications. Chemical Papers 2018, Vol.72, P.1065-1080
  7. Archi Sharma, Satish Gudala, Srinivasa Rao Ambati, Santhosh Penta, Shyama Prasad Mahapatra, Rajeswar Rao Vedula, Someshwar Pola and Bibhudendra Acharya. Synthesis of Heterocyclic Compounds Catalyzed by Metal/Metal Oxide-Multiwall Carbon Nanotube Nanocomposites. Journal Of Chinese Chemical Society, Volume 64, Issue 6, June 2017, Pages 589–606.
  8. Archi Sharma, Gudala Satish and Santhosh Penta. A Facile Synthesis of Aryl-Substituted Hydrazono-Pyrazolyl[1,2,4]triazolo[3,4-b][1,3,4][thiadiazol]-coumarin Derivatives. Journal of Heterocyclic Chemistry. Volume 53, Issue 4, July 2016, Pages: 1086–1090
  9. Gudala Satish, Archi Sharma, Kranthi Kumar Gadidasu, Rajeswar Rao Vedula, Santhosh Penta. Synthesis and antibacterial activity of 2-pyranyl-4-aryl-7,8-dihydro-quinoline derivatives catalyzed by cerium ammonium nitrate via multi-component reaction. Chemistry of Heterocyclic Compounds, June 2016, Volume 52, Issue 6, pp 409-414.
  10. Santhosh Penta and Rajeswar Rao Vedula, An efficient one-pot synthesis of pyrazolyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-2H-pyran-2-one derivatives via multicomponent approach and their potential antimicrobial and nematicidal activity. Tetrahedron  Letters-2013, 54, 5663-5666
  11. Santhosh Penta and Rajeswar Rao Vedula, Synthesis of 2,4,6-tri-substituted pyridine derivatives in aqueous medium via Hantzsch multicomponent reaction catalyzed by cerium (IV) ammonium nitrate. Journal of Heterocyclic Chemistry-2013, Vol.50, 859-862
  12. Santhosh Penta and Rajeswar Rao Vedula, A new convenient, one pot method for the synthesis of Thiazolyl-pyrazolones from dehydroacetic acid derivative via multicomponent approach. Synthetic Communication-2012, Vol.42, 3395-3402
  13. Santhosh Penta and Rajeswar Rao Vedula, Environmentally friendly, one-pot synthesis of substituted thiazoles and thiazolyl-pyrazoles. Russian Journal of General Cemistry-2012, 82, 1464-1467.
  14. Santhosh Penta and Rajeswar Rao Vedula, A facile one-pot synthesis of 1,3,4-thiadiazine-5-yl-pyran-2-one derivatives via multicomponent reaction. Journal of Sulfur Chemistry: 2011, Vol. 32, 327-333
  15. Santhosh Penta and Rajeswar Rao Vedula, One-pot synthesis of tri-substituted pyrazoles via multicomponent approach. Chemistry of Heterocyclic Compounds:   2011, No.4, 547-551



  1. Tewodros Birhanu Aychiluhim, Santhosh Penta & Vedula Rajeswar Rao One-pot synthesis of 4-(arylidene)-2-[5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-thiazol-2-yl]-5-methyl-2,4-dihydro-pyrazol-3-ones via multi-component approach. Indian Journal of Chemistry-2014, 53B, 1242-1246.
  2. Santhosh Penta and Rajeswar Rao Vedula, An efficient improved one-pot synthesis of thiazolo[2,3-c][1,2,4]triazol-5-yl)-2H-chromen-2- one derivatives via multi-component approach. Indian Journal of Chemistry-2012, 53B, 115-119.



  1. Presented a paper in National Seminar on “New Vistas in Chemistry During 21st Century” 11th-12th September 2009, held at Pingle Govt. College for Women, Warangal.
  2. Presented a paper in International Conference on “Recent advances in drug discovery” 22nd-24th October, 2010, held at Kakatiya University, Warangal.
  3. Presented a paper in National Conference on “Recent Advances in Heterocyclic Chemistry” 4th-5th Nov, 2011, held at JNTU Hyderabad.
  4. Presented a paper in 3rd International Conference on Heterocyclic Chemistry 10th-13th Dec, 2011, held at University of Rajasthan, Jaipur.
  5. Participated in Science Academies lecture workshop on Current Trends In Nanoscience And Technology, December 23rd-24th, 2011, held at Department of Chemistry, National Institute of Technology,  Warangal.
  6. Presented a paper in National Conference on Interface between chemical Sciences and Technologies, 29th-30th December 2011, held at Department of Chemistry, National Institute of Technology, Warangal.
  7. Accepted a paper in 13th Florida Heterocyclic and Synthetic International Conference on “Synthesis of heterocyclic compounds by multi-component reactions” 4th-7th March, 2012, held at, Gainesville, U.S.A.
  8. Participated in short term course on “Recent trends in material science-II” Sep-30th –Oct 4th 2013 Organized by Department of Physics, National Institute of Technology-Raipur, C.G.
  9. Participated in lecture workshop on “Recent Advances in Synthesis and Medicinal Applications of Heterocyclic Compounds" (RASMAHC), November 8th-10th, 2013, held at Department of Chemistry, National Institute of Technology, Warangal.
  10. Given an oral presentation entitled “ A facile synnthesis of pyridinyl 1,2,4-triazinyl-chromen-2-derivatives via multicomponent approach” for oral presentation in 32nd Annual Conference Indian Council of Chemists 28th-30th November 2013, Department of studies in chemistry, Karnatak University, Dharwad.
  11. Given an oral presentation on “an efficient one-pot synthesis of pyran substituted dihydropyrimidine-2(1H)-ones and thiones and their anticancer activity:  A Biginelli approach” in International Conference (organized by        department of chemistry vikrama Simhapuri University and UNT health science center Fort Worth, Texas, USA) conducted in vikrama simhapuri university, Nellore, Andhra Pradesh on 27-29 December 2013.
  12.  Accepted a paper in 6th international conference on Drug Discovery & Therapy on “synthesis of novel 1-(4-(2H-chromen-3-yl)thiazol-2-yl)-3,5 dimethyle-2-phenyl-1-H-,2-H-,3,4 bi pyrazole-5-ol derivatives” on feb-10-12,     2014, held at Dubai.
  13. Given an oral presentation on “A facile synthesis of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl-pyran-2-one derivatives via ring transformation reaction” in Recent Development in Chemical Science and Technology: Young Scientists’ Meet (RDCST -2014) 15-16 March. (NIT, ROURKELA).
  14. Given a lecture on “Modification Strategies for Development of Bioactive Heterocyclic Compounds” in Short term Training Programme on Recent Trends in Heterocyclic Compounds and Material Science, organized by Dept of Chemistry, NIT-Raipur, 26-30, May 2014.
Other Info.


 A. Book Title:

Advances in Structure and Activity Relationship of Coumarin Derivatives

ISBN No: 9780128037973 

Editor: Dr. Santhosh Penta

Publisher: Elsevier


B. Book Title:

Dehydroacetic Acid and Its Derivatives: Useful Synthons in Organic Synthesis

eBook  ISBN: 9780081019276

Editor: Dr. Santhosh Penta

Publisher: Elsevier 


SPONSORED PROJECTS (Ongoing)                                            

  • Project entitled “Design and synthesis of novel potent heterocyclic compounds and their biological evaluation” for a period of 3 years (2014-2017) by Chhattisgarh Council of Science and Technology (Rs. 4,95,000.00) as Principal Investigator

  • “Feasibility Studies on Removal of Contaminants from Surface and Ground Water of Bailadila Iron Ore Mine Project and Peripherals” for a period of 3 years (2018-2021) by NMDC Limited (A Govt of India Enterprice) (Rs. 66.58 Lakhs) as Co-Principal Investigator.



  1. Ms. Archi Sharma (Awarded)
  2. Mr. Gudala Satish (Awarded)
  3. Mr. Srinivasa Rao Ambati (On-going)
  4. Mr. Srishylam (On-going)
  5. Mr. Jeevanlal Patel (On-going)
  6. Ms. Komal Chandrakar (On-going)



SHORT TERM TRAINING PROGRAMME ORGANISED                                                   

  •  “Recent Trends in Heterocyclic Compounds and Material Science” from May 26-30, 2014,    Department of Chemistry, NIT-Raipur.

          Coordinators: Dr. Santhosh Penta and Dr. S.P. Mahapatra



  1. Chemistry Select
  2. Organic & Biomolecular Chemistry 
  3. Synthetic Communications
  4. Journal of Heterocyclic Chemistry
  5. Journal of Sulfur Chemistry
  6. Chemistry of Heterocyclic Compounds

 MEMBERSHIP IN SCIENTIFIC SOCIETY                                                                          


  • Since 2013      :     Life time member, Indian Council of Chemists, Agra, India
  • Since 2013      :     Life time member, The Indian Science Congress Association, India
  • Since 2013      :     Life time member, Materials Research Society of India, IISC, India
  • Since 2013      :     Life time member, Indian Chemical Society, Kolkata, India



  • Expertise in multi-step synthesis.
  • Reflective knowledge and good skills in synthesis of heterocyclic molecules.
  • Capable of designing and development of new strategies for biological active compounds.
  • Extensively worked on chromatographic separation and structure analysis.
  • Experiences in parallel synthesis include the design, synthesis, purification and characterization of new chemical entities
  • Capable of carrying independent and collaborative research work.
  • Profound efficiency in handling of hygroscopic, air sensitive reagents and reactions.